PGS (preimplantation genetic screening | Forsa Fertility

PGS

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    PGS of 1 embryo 450 €
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    Recommended to women 37+ with a history of miscarriage or failed IVF cycles
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    Chromosomal abnormalities identification
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    Guarantee of a healthy child. Free of any genetic disorders
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    5-7 days. results waiting time

What is Preimplantation genetic screening (PGS)?

PGS (nowadays known as PGT-A) is a technique where embryos are examined for overall chromosome level to find out about any potential genetic abnormalities.

In contrast to Preimplantation Genetic Diagnosis, patients undergoing Preimplantation Genetic Screening are not carriers of a genetic disorder and they have a normal karyotype. The aim of PGS is to identify aneuploidy embryos that is embryos that have an abnormal number of chromosomes. Aneuploidies are a major cause of failed implantations, miscarriages, and birth defects.

Among the common genetic conditions caused by abnormal chromosome count there are Down syndrome, Turner syndrome, and Klinefelter syndrome.

Advantages of PGS:

  • With the help of the NGS genetic testing is possible to study the complete chromosome set of embryos before their transfer to the uterus.
  • This makes it possible to identify not only more common chromosomal abnormalities (for example Down's syndrome), but also rare violations in the set of chromosomes, up to small doublings (duplications) or losses (deletions) in the structure of chromosomes.
  • It is also important to use the NGS testing in invasive prenatal diagnosis. The development of fetal malformations is often associated with chromosome abnormalities, both quantitative and structural (microdeletions, microduplications).

Who is Preimplantation Genetic screening is suitable for?

  • The woman is aged 38 or older.
  • There is a history of recurrent miscarriage.
  • There has been repeated IVF failure, for example 5 or more embryos have been replaced without success.
  • There has previously been a chromosomally abnormal pregnancy (e.g. Down syndrome).

What is the process of chromosome testing by PGS?

  1. Chromosome testing by next generation sequencing involves taking a few cells from a developing embryo for testing.
  2. Next generation sequencing amplifies DNA from the cell’s nucleus by multiplying it many thousand of times before using sequencing technology to count the number of copies of each chromosome present in the cells from the embryo.
  3. This allows the scientists to accurately detect chromosomal errors, so only an embryo with a normal chromosome profile is selected for transfer, increasing the chance of a successful pregnancy.While the majority of biopsies are undertaken on Day 5 embryos, we have the flexibility to undertake the biopsy on any day during embryo development depending on the patient’s individual circumstances.

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