Advantages of PGD:
- With the help of the NGS genetic testing is possible to study the complete chromosome set of embryos before their transfer to the uterus.
- This makes it possible to identify not only more common chromosomal abnormalities (for example Down's syndrome), but also rare violations in the set of chromosomes, up to small doublings (duplications) or losses (deletions) in the structure of chromosomes.
- It is also important to use the NGS testing in invasive prenatal diagnosis. The development of fetal malformations is often associated with chromosome abnormalities, both quantitative and structural (microdeletions, microduplications).
Who is Preimplantation Genetic Diagnosis is suitable for?
- PGD is recommended for couples that have a genetic predisposition and/or have any probability of passing down a known genetic abnormality. Any couple with a family history of aneuploidy (abnormal number of chromosomes) which results in miscarriage, birth defects, or Down Syndrome can be screened.
- In addition, families that have a history of single-gene defects—such as cystic fibrosis, sickle cell anemia, and muscular dystrophy—can consider PGD testing.
- Through this procedure, the highly skilled laboratory staff at New England Fertility will determine which embryos are unaffected and therefore the most viable for uterine transfer.