NGS of 1 embryo 450 €
24 chromosomes tested
Chromosomal abnormalities identification
Biopsy on day 5 of embryo development
What is NGS?
Next Generation Sequencing (NGS) is a pre-implantation genetic testing technique, often used combined with PGS. NGC screens all the twenty-four chromosomes in an embryo and provides comprehensive data on the DNA of the given embryo in terms of diseases or genetic mutations.
With NGS, all 24 chromosomes are screened simultaneously and this helps embryologists select only the best quality embryos for embryo transfer.
Advantages of NGS genetic testing
- With the help of the NGS genetic testing is possible to study the complete chromosome set of embryos before their transfer to the uterus.
- This makes it possible to identify not only more common chromosomal abnormalities (for example Down's syndrome), but also rare violations in the set of chromosomes, up to small doublings (duplications) or losses (deletions) in the structure of chromosomes.
- It is also important to use the NGS testing in invasive prenatal diagnosis. The development of fetal malformations is often associated with chromosome abnormalities, both quantitative and structural (microdeletions, microduplications).
Who is next generation sequencing suitable for?
- The woman is aged 38 or older.
- There is a history of recurrent miscarriage.
- There has been repeated IVF failure, for example 5 or more embryos have been replaced without success.
- There has previously been a chromosomally abnormal pregnancy (e.g. Down syndrome).
What is the process of chromosome testing by next generation sequencing?
Chromosome testing by next generation sequencing involves taking a few cells from a developing embryo for testing.
Next generation sequencing amplifies DNA from the cell’s nucleus by multiplying it many thousand of times before using sequencing technology to count the number of copies of each chromosome present in the cells from the embryo.
This allows the scientists to accurately detect chromosomal errors, so only an embryo with a normal chromosome profile is selected for transfer, increasing the chance of a successful pregnancy.While the majority of biopsies are undertaken on Day 5 embryos, we have the flexibility to undertake the biopsy on any day during embryo development depending on the patient’s individual circumstances.
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