Which patients will benefit most most from egg donation + NGS treatment?
TNGS method used with egg donation treatment can significantly increase the pregnancy success rates in such program. It also greatly reduces the likelihood of having a baby with genetic pathologies. NGS is recommended for patients who have already undergone several IVF attempts without success or have had multiple miscarriages in early pregnancy.
NGS 24 chromosomes Your way to successful pregnancy and a healthy baby
Next Generation Sequencing is a pre-implantation genetic testing method in which all 24 chromosomes of an embryo are screened in order to identify genetic abnormalities. NGS, as a part of an IVF program, enables embryologists to select the embryos with a healthy chromosome profile. Only these embryos can then be transferred to the patient’s uterus. It is crucial to stress that NGS testing offers a very low error rate and is very reliable method.
Success Rates - Egg Donation + NGS
- 86% for women under 30.
- 82% for women aged 31-35.
- 78% for women aged 36-39.
- 76% for women aged 40-42.
- 70% for women aged 43-45.
Indications for egg donation + NGS program
- premature ovarian failure syndrome,
- violation of ovarian structure,
- genetic diseases transmitted through the female line (if the patient does not agree to PGD),
- previous failed IVF cycles due to ovarian failure,
- infertility caused by exposure to radiation or chemicals,
- previous failed insemination attempts,
- age-related infertility,
- recurrent miscarriages,
- polycystic ovary syndrome (PCOS),
- male factor: low count or motility of spermatozoa or altered percentage of their abnormal forms,
- obstruction or ligation of the fallopian tubes,
- single motherhood by choice,
- lesbian, bisexual or transgender motherhood,
- a medical history of genetic diseases,
- unexplained infertility.
Advantages Of Egg Donation+NGS program
- Undergoing an egg donation program and using oocytes from a young and healthy donor means that the age of the recipient mother is not a factor for a successful conception.
- Egg donation treatment is very effective, therefore, it is an ideal solution for women suffering from premature ovarian failure, repeated miscarriages and similar issues.
- Women who are not able to have a successful pregnancy via IVF with own eggs, but are not ready for adoption, can experience the joy of pregnancy and giving birth to their own donor egg baby.
- The intended parents can choose a donor on the basis of information stored in our egg bank. Patients can view the donor’s age, blood group, eye and hair colour, height, education. For some couples, appearance is a top priority. Choosing a donor that looks like them makes it more likely that the baby will inherit the desired traits. Some patients choose to focus more on the donor’s education. For example, if you are a fan of science, you may choose a donor who has studied the subject or lists science as one of her main interests.
- Since the program involves young egg donors who have been thoroughly screened, there is no risk of chromosomal and genetic diseases occurring in the child.
- NGS significantly increases the effectiveness of the IVF program. The high accuracy of determining chromosomal abnormalities (99.9%) allows not only to avoid the risk of having a child with severe hereditary diseases but also to boost the success rates of embryo implantation.
Egg Donation + NGS Process. Step By Step
- First contact.
Validation of medical information and screening
- Consultation and
IVF treatment procedure
- Endometrial preparation
- Donor’s egg collection
- Іn vitro fertilization
- Embryo culture
- Embryo transfer
- Pregnancy testLearn more
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Egg Donation + NGS process
Validation of medical information and screening
To start the program, you need to contact by email or WhatsApp the coordinator of Forsa Fertility. He will provide you with a list of tests that you need to do before arrival as well as a questionnaire that you need to fill out. After the validation of your records by our doctor, we will set up the first appointment with you (depending on the reception hours and availability of our doctor).
IVF treatment procedure.
The first visit includes: consultation with our gynaecologist, medical tests (serology + smears + karyotype + blood tests + hormonology + sperm collection). At the time of the consultation, our gynaecologist will establish the protocol for you in advance. According to the stimulation protocol, you will know the date of the IVF and the transfer.
The donor will take the drugs for the growth of the follicles (oocytes), these will be the hormonal injections. We will monitor the development of follicles. For IVF to be successful it is necessary to obtain a few mature eggs during a menstrual cycle. This possibility is achieved by drugs such as Puregon, Merional, Gonal and others. These drugs help control the menstruation cycle and the maturation of the oocytes
Donor’s egg collection
In the IVF program, the transvaginal puncture of ovarian follicles is the final stage of stimulation for a donor. The procedure is carried out simultaneously with the collection of sperm from the intended father. Puncture of follicles during the IVF process has the only purpose – collection of a sufficient number of mature oocytes from the donor for their subsequent fertilization in the laboratory. The ovarian puncture is performed under general anaesthesia.
In vitro fertilization
In vitro procedure is carried out by the embryologists in the embryological laboratory. After the oocytes aspiration, they are combined with the husband's sperm and placed in an incubator-thermostat where fertilization takes place.
On the second or third day after fertilization, the embryos are assessed for the feasibility of their further cultivation. If there is a sufficient number of dividing embryos, they are placed in the special medium and cultured for two or three additional days.
The purpose of extended culture is to select for transfer the embryos that have reached the blastocyst stage and will give a higher chance of pregnancy.
This procedure is carried out in the embryological laboratory: experts take material for analysis on the fifth day of embryo development. The process is fully automated which excludes the impact of the human factor. The material is obtained from the outer layer of the embryo due to which the risks for its further development are minimized. Since in vitro embryos can live up to five days, and the analysis takes time, a cryo cycle is performed. Embryos are frozen ultra-quickly and then transferred in the next cycle – in the period most suitable for conception. Thus, doctors can carry out the NGS procedure and better prepare a woman for pregnancy: stabilize hormonal levels, make sure the endometrium is ready for implantation.
The embryo transfer procedure does not require anaesthesia as it is absolutely painless. With the help of a small-diameter guidewire, a catheter with the special medium is inserted through the cervix into the uterine cavity where one or more embryos are placed. After the end of the embryo transfer procedure, a woman can go home in a few hours.
After the embryo transfer, assessment of the level of chorionic gonadotropin in the blood is the most reliable method for determining early pregnancy. After carrying out the embryo transfer in the infertility treatment program, it is recommended to determine the level of hCG in the blood on the 12-14th day.